Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ.

@article{Draper2011Omega3FA,
  title={Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ.},
  author={Eve Draper and Clare M. Reynolds and Mary Canavan and Kingston H G Mills and Christine E. Loscher and Helen M. Roche},
  journal={The Journal of nutritional biochemistry},
  year={2011},
  volume={22 8},
  pages={784-90}
}
Long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) have been shown to modulate the immune response and have therapeutic effects in inflammatory disorders. PUFA are also peroxisome proliferators-activator receptor-gamma (PPARγ) ligands; a family of ligand-activated transcription factors, which when activated antagonise the pro-inflammatory capability of nuclear factor κB (NF-κB). PPARγ plays a role in dendritic cell (DC) maturation and n-3 PUFA have been shown to affect DC maturation by… CONTINUE READING

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