Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3

  title={Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3},
  author={Fr{\'e}d{\'e}ric Darios and Bazbek Davletov},
Growth of neurite processes from the cell body is the critical step in neuronal development and involves a large increase in cell membrane surface area. Arachidonic-acid-releasing phospholipases are highly enriched in nerve growth cones and have previously been implicated in neurite outgrowth. Cell membrane expansion is achieved through the fusion of transport organelles with the plasma membrane; however, the identity of the molecular target of arachidonic acid has remained elusive. Here we… 
Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells[S]
Light is shed on the novel role of LpEs in the central nervous system and also a novel pathway in which PUFAs act on neurons, which is demonstrated to exhibit a strong effect on neurite outgrowth of hippocampal neurons.
Arachidonic acid potentiates exocytosis and allows neuronal SNARE complex to interact with Munc18a
It is demonstrated that an n‐6 series polyunsaturated fatty acid, arachidonic acid, potentiates secretion from intact neurosecretory cells regardless of the secretagogue used and that Munc18a can interact with the neuronal SNARE complex in a dose‐dependent manner.
Natural lecithin promotes neural network complexity and activity
It is suggested that lecithin nanoliposomes enhance neuronal development, which may have an impact on devising new leCithin delivery strategies for therapeutic applications.
Dietary polyunsaturated fat that is low in (n-3) and high in (n-6) fatty acids alters the SNARE protein complex and nitrosylation in rat hippocampus.
It is suggested that altered SNARE complex binding or disassembly could be important in explaining the diverse cellular events associated with altered tissue DHA.
Lipids in Regulated Exocytosis: What are They Doing?
The latest evidence supporting the concept of the fusogenic activity of lipids is reviewed, and how this may be achieved is discussed.
Gene and protein expression profiling of the fat-1 mouse brain.


Arachidonic Acid Turnover and Phospholipase A2 Activity in Neuronal Growth Cones
The predominance of PLA2 activity in GCPs raises questions regarding its regulation and the functional roles of PI metabolites, especially lysocompounds, in growth cones.
Promiscuous interaction of SNAP-25 with all plasma membrane syntaxins in a neuroendocrine cell.
It is shown that rat phaeochromocytoma PC12 cells contain large amounts of SNAP-25, which interacts not only with syntaxin 1, but also with ubiquitous syntaxins 2, 3 and 4, suggesting that the plasma membrane syntaxins may mediate vesicle fusion events with different properties.
Role of Protein Kinase C α in Nerve Growth Factor‐Induced Arachidonic Acid Release from PC12 Cells
It is suggested that PKC α plays a role in NGF‐induced AA release, as well as that PMA alone can induce AA release in PC12 cells, which suggest thatPKC is necessary for NGF •inducedAA release.
Characterization of Phospholipase A2 Activity Enriched in the Nerve Growth Cone
Growth cones contain two high‐molecular‐weight forms of phospholipase A2 that share many properties with known, Ca2+‐independent cytosolic phospholips A2 species but that appear to be monoselective for PI and PE, respectively.
Arachidonic acid as a bioactive molecule.
  • A. Brash
  • Biology, Chemistry
    The Journal of clinical investigation
  • 2001
The solubility properties of the molecule are considered, which are crucial to understanding the availability within the cell of endogenous and exogenous arachidonic acid, and selected biological actions of this lipid are turned to.
Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals.
  • M. Wenk, P. De Camilli
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
Powerful methods for the detection of lipids are rapidly advancing this field, thus complementing the broad range of information about biological systems that can be obtained from genomic and proteomic approaches.
Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you.
The various functions of DHA in the nervous system, the proteins involved in its internalization and metabolism into phospholipids, and its relationship to several neurological disorders, including Alzheimer's disease and depression are reviewed.
Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo
It is reported here that SNAP-25 is expressed in axonal growth cones during late stages of elongation and that selective inhibition of SNAP- 25 expression prevents neurite elongation by rat cortical neurons and PC-12 cells in vitro and by amacrine cells of the developing chick retina in vivo.