Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling.

@article{Caires2017Omega3FA,
  title={Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling.},
  author={Rebeca C. Caires and Francisco J. Sierra-Valdez and Jonathan Millet and Joshua D Herwig and Esra Roan and Valeria V{\'a}squez and Julio F. Cordero-Morales},
  journal={Cell reports},
  year={2017},
  volume={21 1},
  pages={
          246-258
        }
}
  • Rebeca C. Caires, Francisco J. Sierra-Valdez, +4 authors Julio F. Cordero-Morales
  • Published in Cell reports 2017
  • Biology, Medicine
  • Dietary consumption of ω-3 polyunsaturated fatty acids (PUFAs), present in fish oils, is known to improve the vascular response, but their molecular targets remain largely unknown. Activation of the TRPV4 channel has been implicated in endothelium-dependent vasorelaxation. Here, we studied the contribution of ω-3 PUFAs to TRPV4 function by precisely manipulating the fatty acid content in Caenorhabditis elegans. By genetically depriving the worms of PUFAs, we determined that the metabolism of… CONTINUE READING

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