Omalizumab in patients with chronic spontaneous urticaria: a systematic review and GRADE assessment

  title={Omalizumab in patients with chronic spontaneous urticaria: a systematic review and GRADE assessment},
  author={M. C. Urgert and M. T. van den Elzen and Andr{\'e} Knulst and Zbys Fedorowicz and Esther J van Zuuren},
  journal={British Journal of Dermatology},
Chronic spontaneous urticaria (CSU) is characterized by the occurrence of hives, angio‐oedema or both for a period of at least 6 weeks. Many patients remain symptomatic despite treatment with H1 antihistamines, even at higher doses. This systematic review assessed the quality of the evidence for the effects of omalizumab as treatment in patients with CSU. We searched PubMed, the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials up to 7 August 2014… 

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