Omalizumab facilitates rapid oral desensitization for peanut allergy

  title={Omalizumab facilitates rapid oral desensitization for peanut allergy},
  author={Andrew MacGinnitie and R. Rachid and Hana Gragg and S. Little and Paul R Lakin and A. Cianferoni and J. Heimall and M. Makhija and R. Robison and S. Chinthrajah and John J Lee and Jennifer S LeBovidge and T. Dominguez and C. Rooney and M. O. Lewis and J. Koss and Elizabeth Burke-Roberts and K. Chin and T. Logvinenko and J. Pongracic and D. Umetsu and J. Spergel and K. Nadeau and L. Schneider},
  journal={The Journal of Allergy and Clinical Immunology},
  • Andrew MacGinnitie, R. Rachid, +21 authors L. Schneider
  • Published 2017
  • Medicine
  • The Journal of Allergy and Clinical Immunology
  • Background: Peanut oral immunotherapy is a promising approach to peanut allergy, but reactions are frequent, and some patients cannot be desensitized. The anti‐IgE medication omalizumab (Xolair; Genentech, South San Francisco, Calif) might allow more rapid peanut updosing and decrease reactions. Objective: We sought to evaluate whether omalizumab facilitated rapid peanut desensitization in highly allergic patients. Methods: Thirty‐seven subjects were randomized to omalizumab (n = 29) or placebo… CONTINUE READING
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