Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses.

@article{Bohovych2016Oma1LM,
  title={Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses.},
  author={Iryna Bohovych and Stavroula Lila Kastora and Sara Christianson and Danelle Topil and Heejeong Kim and Teresa E Fangman and You Zhou and Antoni Barrientos and Jaekwon Lee and Alistair J P Brown and Oleh Khalimonchuk},
  journal={Molecular and cellular biology},
  year={2016},
  volume={36 17},
  pages={
          2300-12
        }
}
A network of conserved proteases known as the intramitochondrial quality control (IMQC) system is central to mitochondrial protein homeostasis and cellular health. IMQC proteases also appear to participate in establishment of signaling cues for mitochondrion-to-nucleus communication. However, little is known about this process. Here, we show that in Saccharomyces cerevisiae, inactivation of the membrane-bound IMQC protease Oma1 interferes with oxidative-stress responses through enhanced… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Mitohormesis

  • J Yun, T Finkel
  • Cell Metab
  • 2014

Mitohormesis. Cell Metab 19:757–766

  • J Yun, T. Finkel
  • http://dx
  • 2014
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