Oltipraz regulates different categories of genes relevant to chemoprevention in human hepatocytes.

Amélie Piton, Eric Le Ferrec, +5 authors Fabrice Morel
Published 2005 in Carcinogenesis

Abstract

Numerous chemical compounds are cytotoxic or carcinogenic to human beings and attention is now focusing on preventative strategies. One agent, oltipraz (OPZ), regarded as one of the most promising chemoprotectors, has been shown to be a potent inducer of phase II enzymes involved in the detoxification of carcinogens, including aflatoxins. However, little is… (More)

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References

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Showing 1-10 of 34 references

S Langouet, F Morel, A Guillouzo
Phytochemicals in Health and Disease. Marcel…
2004

Oltipraz genes targets in human hepatocytes
2004

A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites.

Timothy J Haggerty, Karen I Zeller, Rebecca C Osthus, Diane R Wonsey, Chi V Dang
Proceedings of the National Academy of Sciences…
2003

Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz.

Keon Wook Kang, Il Je Cho, Chang Ho Lee, Sang Geon Kim
Journal of the National Cancer Institute
2003

Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.

Asher Begleiter, Kosala Sivananthan, Thomas J Curphey, Ranjana P Bird
Cancer epidemiology, biomarkers & prevention : a…
2003

Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.

Nathan J Cherrington, Angela L Slitt, +6 authors Curtis D Klaassen
Drug metabolism and disposition: the biological…
2003

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.

Mi-Kyoung Kwak, Nobunao Wakabayashi, Ken Itoh, Hozumi Motohashi, Masayuki Yamamoto, Thomas W Kensler
The Journal of biological chemistry
2003

Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products.

Judy L Raucy
Drug metabolism and disposition: the biological…
2003

K S Yao, O Dwyer
Biochem. Pharmacol
2003

Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes.

Antonietta Martelli, Francesca Mattioli, Marianna Angiola, Roland Reimann, Giovanni Brambilla
Mutation research
2003

Oltipraz regulates different categories of genes relevant to chemoprevention in human hepatocytes.

Abstract

Topics

3 Figures and Tables

Cited By

Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.

Low level occupational exposure to styrene: its effects on DNA damage and DNA repair.

General review on in vitro hepatocyte models and their applications.

Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures.

Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.

Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.

Short Communication FUNCTIONAL EXPRESSION OF SINUSOIDAL DRUG TRANSPORTERS IN PRIMARY HUMAN AND RAT HEPATOCYTES

References

Effect of oltipraz on phase I and phase II xenobiotic metabolizing enzymes

Oltipraz genes targets in human hepatocytes

A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites.

Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz.

Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.

Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.

Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products.

Role of the AP-1 element and redox factor-1 (Ref-1) in mediating transcriptional induction of DT-diaphorase gene expression by oltipraz: a target for chemoprevention

Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes.

Slides referencing similar topics

Oltipraz regulates different categories of genes relevant to chemoprevention in human hepatocytes.

Abstract

Topics

3 Figures and Tables

Cited By

Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.

Low level occupational exposure to styrene: its effects on DNA damage and DNA repair.

General review on in vitro hepatocyte models and their applications.

Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures.

Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.

Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.

Short Communication FUNCTIONAL EXPRESSION OF SINUSOIDAL DRUG TRANSPORTERS IN PRIMARY HUMAN AND RAT HEPATOCYTES

References

Effect of oltipraz on phase I and phase II xenobiotic metabolizing enzymes

Oltipraz genes targets in human hepatocytes

A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites.

Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz.

Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.

Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.

Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products.

Role of the AP-1 element and redox factor-1 (Ref-1) in mediating transcriptional induction of DT-diaphorase gene expression by oltipraz: a target for chemoprevention

Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes.

Similar Papers

Slides referencing similar topics