Olsalazine in maintenance of clinical remission in patients with ulcerative colitis

@article{CHB1993OlsalazineIM,
  title={Olsalazine in maintenance of clinical remission in patients with ulcerative colitis},
  author={Frcp PhD Prof. J. P. Wright MB CHB and Mrcp E. A. O'Keefe BM BCH and Lapin Ba and MRCPath PhD K. Jaskiewicz},
  journal={Digestive Diseases and Sciences},
  year={1993},
  volume={38},
  pages={1837-1842}
}
Frequent minor side effects are associated with sulfasalazine. The realization that it is the 5-aminosalicylic acid moiety that is the active component of sulfasalazine and that the side effects are probably due to the sulfapyridine has prompted the search for a similar but safer compound. Olsalazine, consisting of two molecules of 5-ASA without sulfasalazine may avoid the problems due to sulfasalazine. One hundred one patients were entered into a double-blind placebo-controlled study of the… CONTINUE READING

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[Induction and maintenance of remission in ulcerative colitis].

  • Gastroenterologie clinique et biologique
  • 2004
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References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

Clinical tolerance of olsalazine

G Jirnerot
  • Scand J Gastroenterol 23(suppl):21-23,
  • 1988
VIEW 1 EXCERPT

Effect of azodisal sodium and sulfasalazine on ileostomy output of fluid, PGE z and P G F ~ in subjects with a permanent !leostomy

H Sandberg-Gertzen, G Jirnerot, K Bukhave, K Laurisen, F Rash-Masden
  • Gut 27:1306-1311,
  • 1986
VIEW 1 EXCERPT

Das KM: Sulfasalazine: Adverse effects and desensitization

SL Taffet
  • Dig Dis Sci 28:833-842,
  • 1983
VIEW 1 EXCERPT