Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.

@article{LopezSambrooks2016OligosaccharyltransferaseII,
  title={Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.},
  author={Cecilia Lopez-Sambrooks and Shiteshu Shrimal and Carol Khodier and Daniel P Flaherty and Natalie Rinis and Jonathan C Charest and Ningguo Gao and Peng Zhao and Lance Wells and Timothy A. Lewis and Mark A. Lehrman and Reid Gilmore and Jennifer E Golden and Joseph N. Contessa},
  journal={Nature chemical biology},
  year={2016},
  volume={12 12},
  pages={
          1023-1030
        }
}
Asparagine (N)-linked glycosylation is a protein modification critical for glycoprotein folding, stability, and cellular localization. To identify small molecules that inhibit new targets in this biosynthetic pathway, we initiated a cell-based high-throughput screen and lead-compound-optimization campaign that delivered a cell-permeable inhibitor, NGI-1. NGI-1 targets oligosaccharyltransferase (OST), a hetero-oligomeric enzyme that exists in multiple isoforms and transfers oligosaccharides to… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

The promise and peril of chemical probes

  • CH Arrowsmith
  • Nat Chem Biol
  • 2015

Structural basis of substrate specificity of human oligosaccharyl transferase subunit N33/Tusc3 and its role in regulating protein N-glycosylation

  • E Mohorko
  • 2014

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon

  • S Pfeffer
  • Nat Commun
  • 2014

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