Oligosaccharides from Agar Inhibit Pro-Inflammatory Mediator Release by Inducing Heme Oxygenase 1

@article{Enoki2010OligosaccharidesFA,
  title={Oligosaccharides from Agar Inhibit Pro-Inflammatory Mediator Release by Inducing Heme Oxygenase 1},
  author={Tatsuji Enoki and Shinji Okuda and Yoko Kudo and Fuyuko Takashima and Hiroaki Sagawa and Ikunoshin Otsu-shi Kato},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2010},
  volume={74},
  pages={766 - 770}
}
  • T. Enoki, S. Okuda, +3 authors I. Kato
  • Published 23 April 2010
  • Medicine, Biology
  • Bioscience, Biotechnology, and Biochemistry
We investigated whether agaro-oligosaccharides have any immunological effects on RAW264.7 mouse macrophages and human monocytes in vitro. We demonstrate that agaro-oligosaccharides suppressed the elevated levels of nitric oxide, prostaglandin E2, and such pro-inflammatory cytokines as tumor necrosis factor-α, interleukin-1β and interleukin-6 in lipopolysaccharide-stimulated monocytes and macrophages. We also demonstrate that those effects of agaro-oligosaccharides on activated monocytes and… 
Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression
TLDR
It is inferred that AGO administration inhibits TNBS-induced colitis in mice through HO-1 induction in macrophages, and oral administration of AGOs might be an important therapeutic strategy for inflammatory bowel disease.
Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression
TLDR
It is inferred that AGO administration inhibits TNBS-induced colitis in mice through HO-1 induction in macrophages, and oral administration of AGOs might be an important therapeutic strategy for inflammatory bowel disease.
Anti-tumor-promoting activities of agaro-oligosaccharides on two-stage mouse skin carcinogenesis.
TLDR
It is confirmed that PGE₂ production was suppressed by AGOs intake in TPA-induced ear edema model, and cyclooxygenase-2 and microsomal PGE synthase-1, rate-limiting enzymes in PGES production, were down-regulated by A GOs in human monocytes.
Heme oxygenase-1 and anti-inflammatory M2 macrophages.
Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells.
TLDR
It is suggested that these functional food materials exert an anti-inflammatory action (inhibition of IL‑8 production) in combination with GlcN by cooperatively suppressing the p38 MAPK signaling (phosphorylation).
Neoagarohexaose-mediated activation of dendritic cells via Toll-like receptor 4 leads to stimulation of natural killer cells and enhancement of antitumor immunity
TLDR
Results indicated that DP6 augments antitumor immunity against B16F1 melanoma cells via the activation of DC-mediated NK cells in a TLR4-dependent manner and is a potential candidate adjuvant that acts as an immune cell modulator for the treatment of melanoma.
Agar oligosaccharides ameliorate the intestinal inflammation of male Drosophila melanogaster via modulating the microbiota, and immune and cell autophagy
TLDR
The results showed that AOS used as a nutritional additive in basal food could lengthen the life of SDS‐stimulated male Drosophila and alleviate the injuries of S DS to microvilli and mitochondria in male Dosophila midgut epithelial cells.
Enhanced anti-oxidant activity of neoagarooligosaccharides produced by β-agarase derived from Aquimarina agarilytica NI125
The neoagarooligosaccharides have received growing attention owing to their physiological activities. The aim of this study was the isolation of agarase-producing bacteria for production of agar
Agaro-Oligosaccharides Prevent Myostatin Hyperexpression and Myosin Heavy Chain Protein Degradation in C2C12 Myotubes Induced by Tumor Necrosis Factor- α
Myostatin is a major factor involved in the regulation of skeletal muscle protein mass. High myostatin levels have been associated with an increase in myotube shrinkage. Enhanced myostatin expression
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
TLDR
It is demonstrated here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects and may have an important protective function in inflammatory disease states and thus has potential therapeutic uses.
Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1–dependent pathway
TLDR
It is demonstrated that CO administration is effective as a therapeutic modality in mice with established chronic colitis and a specific signaling pathway, not previously identified, is delineated that involves an obligatory role for HO-1 induction in the protection afforded by CO.
Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis.
TLDR
HO-1 is expressed in RA synovial tissues and plays a regulatory role in the development of inflammation, suggesting that HO-1 induction is a novel therapeutic strategy for RA.
Molecular basis of heme oxygenase-1 induction: implications for chemoprevention and chemoprotection.
TLDR
The scope of this review is limited to focus on molecular mechanisms underlyingHO-1 expression and the significance of targeted induction of HO-1 as a strategy to achieve chemoprevention and chemoprotection.
Suppression of Heme Oxygenase‐1 mRNA Expression by Interferon‐γ in Human Glioblastoma Cells
TLDR
Findings raise the possibility that the expression of heme oxygenase‐1 is down‐regulated by interferon‐γ in the nervous system.
Heme oxygenase 1 (HO‐1) regulates osteoclastogenesis and bone resorption
  • J. Zwerina, S. Tzima, +6 authors G. Schett
  • Chemistry, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2005
TLDR
Data indicate that HO‐1 negatively regulates osteoclastogenesis, leading to a positive net balance of bone in humans, as well as in animal models of acute and chronic inflammation.
Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo
TLDR
It is indicated that PGE2 plays a major role in tissue edema, hyperalgesia, and IL-6 production at sites of inflammation, and it is suggested that selective pharmacologic modulation of P GE2 synthesis or activity may provide a useful means of mitigating the symptoms of inflammatory disease.
Basal Rather Than Induced Heme Oxygenase-1 Levels Are Crucial in the Antioxidant Cytoprotection1
Heme oxygenase-1 (HO-1) overexpression protects against tissue injury in many inflammatory processes, including ischemia/reperfusion injury (IRI). This study evaluated whether genetically decreased
Iron regulates nitric oxide synthase activity by controlling nuclear transcription
TLDR
The results suggest the existence of a regulatory loop between iron metabolism and the NO/NOS pathway, and nuclear run-off experiments demonstrate that nuclear transcription of cytokine-inducible NOS mRNA is strongly increased by desferrioxamine whereas it is decreased by Fe(3+).
Peroxynitrite formation from macrophage-derived nitric oxide.
...
1
2
3
...