Oligosaccharides and discordant xenotransplantation.

@article{Cooper1994OligosaccharidesAD,
  title={Oligosaccharides and discordant xenotransplantation.},
  author={David K. C. Cooper and Eugen Koren and Rafael Oriol},
  journal={Immunological reviews},
  year={1994},
  volume={141},
  pages={31-58}
}
The initiating factor in the hyperacute rejection of pig organs by human or non-human primates is believed to be related to the presence of preformed "natural" antibodies in the host. In 1991, we demonstrated that human anti-pig antibodies were IgG, IgM and IgA and bound most strongly to oligosaccharides with an alpha galactose (alpha Gal) terminal residue. These included (i) alpha Gal-R (alpha galactose), (ii) alpha Gall-3 beta Gal-R (B disaccharide), (iii) alpha Gall-3 beta Gall-4 beta GlcNAc… CONTINUE READING

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