Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi.

  title={Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi.},
  author={Elisabet V. Caler and Silvia Vaena de Avalos and Paul A Haynes and Norma W Andrews and Barbara A Burleigh},
  journal={The EMBO journal},
  volume={17 17},
Mammalian cell invasion by the intracellular protozoan parasite Trypanosoma cruzi is mediated by recruitment and fusion of host cell lysosomes, an unusual process that has been proposed to be dependent on the ability of parasites to trigger intracellular free calcium concentration ([Ca2+]i) transients in host cells. Previous work implicated the T.cruzi serine hydrolase oligopeptidase B in the generation of Ca2+-signaling activity in parasite extracts. Here we show that deletion of the gene… CONTINUE READING
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