Oligonucleotide targeting to alveolar macrophages by mannose receptor-mediated endocytosis.

  title={Oligonucleotide targeting to alveolar macrophages by mannose receptor-mediated endocytosis.},
  author={Waley Wei Jie Liang and Xianglin Shi and Deepa Deshpande and Carl J. Malanga and Yon Rojanasakul},
  journal={Biochimica et biophysica acta},
  volume={1279 2},
Antisense oligonucleotides (ONs) have proven useful for selective inhibition of gene expression. However, their effective use is limited by inefficient cellular uptake and lack of cellular targeting. In this paper, we report a drug targeting system which utilizes mannose receptor-mediated endocytosis to enhance cellular uptake of ONs in alveolar macrophages (AMs). The system employs a molecular complex consisting of partially substituted mannosylated poly(L-lysine) (MPL), electrostatically… CONTINUE READING
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