Oligonucleotide libraries--variatio delectat.

@article{Famulok1998OligonucleotideLD,
  title={Oligonucleotide libraries--variatio delectat.},
  author={Michael Famulok and Andreas Jenne},
  journal={Current opinion in chemical biology},
  year={1998},
  volume={2 3},
  pages={
          320-7
        }
}
In vitro selection of combinatorial nucleic acid libraries leads to specific target-binding molecules--RNA, single stranded DNA, modified RNA or modified DNA, commonly designated as aptamers--and to novel catalytic nucleic acids. The current state of aptamer and ribozyme technology is such that it establishes itself as a means of obtaining useful tools for molecular biology, diagnostics, molecular medicine and bio-organic chemistry. 
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