Oligonucleotide inhibition of Fas as a potential treatment strategy in human liver disease.

Abstract

Fas (CD95 or APO-1) is a member of tumor necrosis factor receptor (TNFR) family. Upon activation, by either binding with Fas ligand or self-aggregation, Fas signaling leads to cell apoptosis. Fas is believed to play a role in T-cell- and B-cell-mediated cytotoxicity and depletion; however, Fas is also constitutively expressed in many tissues, including… (More)

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@article{Zhang2001OligonucleotideIO, title={Oligonucleotide inhibition of Fas as a potential treatment strategy in human liver disease.}, author={H. Zhang and Nicholas M. Dean}, journal={Drug news & perspectives}, year={2001}, volume={14 8}, pages={453-9} }