Oligonucleotide hybridization studied by a surface plasmon diffraction sensor (SPDS).

@article{Yu2004OligonucleotideHS,
  title={Oligonucleotide hybridization studied by a surface plasmon diffraction sensor (SPDS).},
  author={Fang Ping Yu and Danfeng Daphne Yao and Wolfgang Knoll},
  journal={Nucleic acids research},
  year={2004},
  volume={32 9},
  pages={
          e75
        }
}
A novel label-free biosensor concept based on surface plasmon-enhanced diffraction by micro- patterned interfaces was applied to the study of hybridization reactions of target DNA oligonucleotides (15mers and 75mers) from solution to probe DNA oligonucleotides attached via streptavidin to the sensor surface. The self-referencing and quadratic signal amplification mechanism of the sensor allowed highly sensitive detection of the hybridization process. Association and dissociation processes of… CONTINUE READING

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Surface-plasmon ̄uorescence spectroscopy

  • T. Neumann, Johansson, M.-L, D. Kambhampati, W. Knoll
  • Adv. Funct. Mater.,
  • 2002
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