Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P.

@article{Tamanini1999OligomerizationPO,
  title={Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P.},
  author={Filippo Tamanini and Leontine M van Unen and Chris Bakker and Nicoletta Sacchi and Hans Galjaard and Ben A. Oostra and Andr{\'e} T. Hoogeveen},
  journal={The Biochemical journal},
  year={1999},
  volume={343 Pt 3},
  pages={517-23}
}
The absence of fragile-X mental-retardation protein (FMRP) results in fragile-X syndrome. Two other fragile-X-related (FXR) proteins have been described, FXR1P and FXR2P, which are both very similar in amino acid sequence to FMRP. Interaction between the three proteins as well as with themselves has been demonstrated. The FXR proteins are believed to play a role in RNA metabolism. To characterize a possible functional role of the interacting proteins the complex formation of the FXR proteins… CONTINUE READING