Oligomerization of opioid receptors.

  title={Oligomerization of opioid receptors.},
  author={Ivone Gomes and Julija Filipovska and Bryen A Jordan and Lakshmi A Devi},
  volume={27 4},
Opioid receptors belong to the family of G-protein-coupled receptors characterized by their seven transmembrane domains. The activation of these receptors by agonists such as morphine and endogenous opioid peptides leads to the activation of inhibitory G-proteins followed by a decrease in the levels of intracellular cAMP. Opioid receptor activation is also associated with the opening of K(+) channels and the inhibition of Ca(2+) channels. A number of investigations, prior to the development of… CONTINUE READING