Oligomerization of adenosine A2A and dopamine D2 receptors in living cells.

@article{Kamiya2003OligomerizationOA,
  title={Oligomerization of adenosine A2A and dopamine D2 receptors in living cells.},
  author={Toshio Kamiya and Osamu Saitoh and Kazuaki Yoshioka and Hiroyasu Nakata},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={306 2},
  pages={544-9}
}
We investigated whether oligomerization of adenosine A(2A) receptor (A(2A)R) and dopamine D(2) receptor (D(2)R) exists in living cells using modified bioluminescence resonance energy transfer (BRET(2)) technology. Fusion of these receptors to a donor, Renilla luciferase (Rluc), and to an acceptor, modified green fluorescent protein (GFP(2)), did not affect the ligand binding affinity, subcellular distribution, and coimmunoprecipitation of the receptors. BRET was detected not only between Myc-D… CONTINUE READING
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