Oligomerization of Ebola virus VP30 is essential for viral transcription and can be inhibited by a synthetic peptide.

@article{Hartlieb2003OligomerizationOE,
  title={Oligomerization of Ebola virus VP30 is essential for viral transcription and can be inhibited by a synthetic peptide.},
  author={Bettina Hartlieb and Jens Modrof and Elke M{\"u}hlberger and H -D Klenk and Stephan Becker},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 43},
  pages={41830-6}
}
Transcription of Ebola virus (EBOV)-specific mRNA is driven by the nucleocapsid proteins NP, VP35, and L. This process is further dependent on VP30, an essential EBOV-specific transcription factor. The present study addresses the self-assembly of VP30 and the functional significance of this process for viral transcription and propagation. Essential for oligomerization of VP30 is a region spanning amino acids 94-112. Within this region a cluster of four leucine residues is of critical importance… CONTINUE READING