Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation.

  title={Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation.},
  author={Celeste Holz-Schietinger and Douglas M Matje and Madeleine Flexer Harrison and Norbert O Reich},
  journal={The Journal of biological chemistry},
  volume={286 48},
DNMT3A is one of two human de novo DNA methyltransferases essential for regulating gene expression through cellular development and differentiation. Here we describe the consequences of single amino acid mutations, including those implicated in the development of acute myeloid leukemia (AML) and myelodysplastic syndromes, at the DNMT3A·DNMT3A homotetramer and DNMT3A·DNMT3L heterotetramer interfaces. A model for the DNMT3A homotetramer was developed via computational interface scanning and… CONTINUE READING


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