Oligomerization of Cavbeta subunits is an essential correlate of Ca2+ channel activity.

@article{Lao2010OligomerizationOC,
  title={Oligomerization of Cavbeta subunits is an essential correlate of Ca2+ channel activity.},
  author={Q. Lao and E. Kobrinsky and Zhuo Liu and N. Soldatov},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 12},
  pages={
          5013-23
        }
}
  • Q. Lao, E. Kobrinsky, +1 author N. Soldatov
  • Published 2010
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Voltage-gated calcium channels conduct Ca(2+) ions in response to membrane depolarization. The resulting transient increase in cytoplasmic free calcium concentration is a critical trigger for the initiation of such vital responses as muscle contraction and transcription. L-type Ca(v)1.2 calcium channels are complexes of the pore-forming α(1C) subunit associated with cytosolic Ca(v)β subunits. All major Ca(v)βs share a highly homologous membrane associated guanylate kinase-like (MAGUK) domain… Expand
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