Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2.

  title={Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2.},
  author={Carl G. Maki},
  journal={The Journal of biological chemistry},
  volume={274 23},
  • Carl G. Maki
  • Published 1999 in The Journal of biological chemistry
Wild-type p53 is degraded in part through the ubiquitin proteolysis pathway. Recent studies indicate that MDM2 can bind p53 and promote its rapid degradation although the molecular basis for this degradation has not been clarified. This report demonstrates that MDM2 can promote the ubiquitination of wild-type p53 and cancer-derived p53 mutants in transiently transfected cells. Deletion mutants that disrupted the oligomerization domain of p53 displayed low binding affinity for MDM2 and were poor… CONTINUE READING

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