Oligomerization is an intrinsic property of calsequestrin in normal and transformed skeletal muscle.

@article{Maguire1997OligomerizationIA,
  title={Oligomerization is an intrinsic property of calsequestrin in normal and transformed skeletal muscle.},
  author={Patricia B Maguire and Fred Briggs and Niall J. Lennon and Kay Ohlendieck},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={240 3},
  pages={721-7}
}
In skeletal muscle fibers, the high-capacity medium-affinity Ca(2+)-binding protein calsequestrin functions as the major Ca(2+)-reservoir of the sarcoplasmic reticulum. To determine the oligomeric status of calsequestrin, immunoblotting of microsomal proteins following chemical crosslinking was performed. Diagonal non-reducing/reducing two-dimensional gel electrophoresis was employed to unequivocally differentiate between cross-linked species of 63 kDa calsequestrin and calsequestrin-like… CONTINUE READING

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