Oligomeric structure of a prototype retrovirus glycoprotein.

  title={Oligomeric structure of a prototype retrovirus glycoprotein.},
  author={David A Einfeld and Eric Hunter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={85 22},
The structure of the Rous sarcoma virus envelope glycoprotein complex was studied by sedimentation gradient centrifugation analyses of detergent-solubilized wild-type and mutant envelope (env) gene products. These studies show that the envelope glycoprotein forms an oligomer during biosynthesis, which is most likely a trimer, and that this is the form of the complex found in virions. Our results are consistent with oligomer formation and transport out of the endoplasmic reticulum being closely… CONTINUE READING