Oligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondria.

  title={Oligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondria.},
  author={Ran Zalk and Adrian Israelson and Erez S Garty and Heftsi Azoulay-Zohar and Varda Shoshan-Barmatz},
  journal={The Biochemical journal},
  volume={386 Pt 1},
The VDAC (voltage-dependent anion channel) plays a central role in apoptosis, participating in the release of apoptogenic factors including cytochrome c. The mechanisms by which VDAC forms a protein-conducting channel for the passage of cytochrome c are not clear. The present study approaches this problem by addressing the oligomeric status of VDAC and its role in the induction of the permeability transition pore and cytochrome c release. Chemical cross-linking of isolated mitochondria or… CONTINUE READING


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