Oligomeric organization of the B-cell antigen receptor on resting cells

@article{Yang2010OligomericOO,
  title={Oligomeric organization of the B-cell antigen receptor on resting cells},
  author={Jianying Yang and Michael Reth},
  journal={Nature},
  year={2010},
  volume={467},
  pages={465-469}
}
B lymphocytes are activated by many different antigens to produce specific antibodies protecting higher organisms from infection. To detect its cognate antigen, each B cell contains up to 120,000 B-cell antigen receptor (BCR) complexes on its cell surface. How these abundant receptors stay silent on resting B cells and how they can be activated by a molecularly diverse set of ligands is poorly understood. Here we show, with the use of a quantitative bifluorescence complementation assay (BiFC… CONTINUE READING
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