Oligomeric forms of the metastasis-related Mts1 (S100A4) protein stimulate neuronal differentiation in cultures of rat hippocampal neurons.

@article{Novitskaya2000OligomericFO,
  title={Oligomeric forms of the metastasis-related Mts1 (S100A4) protein stimulate neuronal differentiation in cultures of rat hippocampal neurons.},
  author={V. N. Novitskaya and Mariam Grigorian and Marina Kriajevska and Svetlana Tarabykina and Igor Bronstein and Vladimir Berezin and Elisabeth Bock and E. M. Lukanidin},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 52},
  pages={41278-86}
}
Neuronal differentiation and axonal growth are controlled by a variety of factors including neurotrophic factors, extracellular matrix components, and cell adhesion molecules. Here we describe a novel and very efficient neuritogenic factor, the metastasis-related Mts1 protein, belonging to the S100 protein family. The oligomeric but not the dimeric form of Mts1 strongly induces differentiation of cultured hippocampal neurons. A mutant with a single Y75F amino acid substitution, which stabilizes… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

Similar Papers

Loading similar papers…