Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer's disease

@article{Parajuli2013OligomericA,
  title={Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer's disease},
  author={B. Parajuli and Y. Sonobe and H. Horiuchi and H. Takeuchi and T. Mizuno and A. Suzumura},
  journal={Cell Death & Disease},
  year={2013},
  volume={4}
}
  • B. Parajuli, Y. Sonobe, +3 authors A. Suzumura
  • Published 2013
  • Biology, Medicine
  • Cell Death & Disease
  • Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by progressive neuronal loss and cognitive decline. Oligomeric amyloid β (oAβ) is involved in the pathogenesis of AD by affecting synaptic plasticity and inhibiting long-term potentiation. Although several lines of evidence suggests that microglia, the resident immune cells in the central nervous system (CNS), are neurotoxic in the development of AD, the mechanism whether or how oAβ induces microglial neurotoxicity… CONTINUE READING
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