Oligodeoxyribonucleotide length and sequence effects on intramolecular and intermolecular G-quartet formation.

@article{Cheng1997OligodeoxyribonucleotideLA,
  title={Oligodeoxyribonucleotide length and sequence effects on intramolecular and intermolecular G-quartet formation.},
  author={Ankang Cheng and Michael W Van Dyke},
  journal={Gene},
  year={1997},
  volume={197 1-2},
  pages={
          253-60
        }
}
The potential of guanine-rich oligodeoxyribonucleotides (oligos) as nucleic acid drugs is increasingly being investigated, for example, as aptamers against heparin-binding proteins and as purine-motif triplex-forming oligos. However, G-rich oligos can be very polymorphic under physiological conditions, often with the resulting structures possessing vastly different functional capabilities. To better understand the intrinsic oligo parameters that affect their structure, we used nondenaturing gel… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Similar Papers

Loading similar papers…