Oligodendroglial cell death induced by oxygen radicals and its protection by catalase

@article{Kim1991OligodendroglialCD,
  title={Oligodendroglial cell death induced by oxygen radicals and its protection by catalase},
  author={Y. S. Kim and Seung U. Kim},
  journal={Journal of Neuroscience Research},
  year={1991},
  volume={29}
}
The cytotoxic effects of oxygen radicals have been studied in enriched population of mature bovine oligodendrocytes in culture. Oxygen radicals were generated enzymatically by glucose and glucose oxidase, and hypoxanthine and xanthine oxidase combinations. Cytotoxicity was assessed by trypan blue exclusion and percentage lactate dehydrogenase release into the culture media. Incubation of bovine oligodendrocytes with these oxygen radical‐generating systems for 4 hr resulted in significant cell… 
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Mode of cell injury and death after hydrogen peroxide exposure in cultured oligodendroglia cells.
Oxidative stress has been implicated as a causal factor in a wide variety of neurodegenerative diseases. To investigate the direct consequences of oxidative damage on myelin-forming cells, we have…
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Evidence is provided for a key role for GPx-catalase cooperativity in the resistance of mature OLs to H2O2-induced cell death.
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Results indicate that both oxygen radicals and excitotoxic amino acids were involved in the oxidant‐ititiated neurotoxicity of spinal cord neurons.
Peroxide‐scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress
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The objectives of the present study were to compare several parameters important in the ability to scavenge peroxides between astrocytes and oligodendroglia.
Delayed oligodendrocyte degeneration induced by brief exposure to hydrogen peroxide
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Vulnerable oligodendrocytes are exposed to oxidative stress that induces rapid degeneration and ultimately leads to delayed cell death, which is highly relevant to oligodendedrocyte damage and depletion following ischemic, traumatic, or inflammatory insults to the central nervous system (CNS).
Peroxynitrite‐induced oligodendrocyte toxicity is not dependent on poly(ADP‐ribose) polymerase activation
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The results show that peroxynitrite exerts cytotoxic effects on oligodendrocytes in vitro independently of PARP activation, and the effects of the PARP inhibitors 3‐aminobenzamide (3AB) and 5‐iodo‐6‐amino‐1,2‐benzopyrone (INH2BP) on mitochondrial function and cell death in oligod endocrine cells.
Astrocytes and catalase prevent the toxicity of catecholamines to oligodendrocytes
Oligodendroglial cells in culture effectively dispose of exogenous hydrogen peroxide: comparison with cultured neurones, astroglial and microglial cells
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It is demonstrated that oligodendroglial cells in culture have a prominent machinery for the disposal of hydrogen peroxide, which is likely to support the protection of these cells in brain against peroxides when produced by these or by surrounding brain cells.
Effects of Nerve Growth Factor on Glutathione Peroxidase and Catalase in PC 12 Cells
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NGF can provide cytoprotection to PC12 cells by inducing the free radical scavenging enzymes catalase and GSH Px and reducing the number of reactive oxygen species in the cell line.
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