Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate

@article{From2014OligodendrogenesisAM,
  title={Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate},
  author={Renana From and Raya Eilam and Dekel D. Bar-Lev and Smadar Levin-Zaidman and Michael M. Tsoory and Patrizia LoPresti and Michael N. Sela and Ruth Soul{\'e} Arnon and Rina Aharoni},
  journal={Glia},
  year={2014},
  volume={62}
}
Myelinogenesis in the mammal nervous system occurs predominantly postnatally. Glatiramer acetate (GA), a drug for the treatment for multiple sclerosis (MS), has been shown to induce immunomodulation and neuroprotection in the inflamed CNS in MS and in experimental autoimmune encephalomyelitis (EAE). Here we investigated whether GA can affect myelinogenesis and oligodendrogenesis in the developing nervous system under nonpathological conditions. Towards this end we studied myelination in mice… 

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References

SHOWING 1-10 OF 52 REFERENCES

Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate

Results indicate that GA promotes oligodendrogenesis and remyelination through mechanisms that involve the elevation of growth factors conducive for repair.

Glatiramer promotes oligodendroglial cell maturation in a cuprizone-induced demyelination model

Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis

The capacity of glatiramer acetate (GA, Copaxone) to affect the demyelination process and/or lead to remyelinated in mice inflicted by chronic EAE is explored using both scanning electron microscopy and immunohistological methods.

The mechanism of action of glatiramer acetate in multiple sclerosis and beyond.

Remyelination In Multiple Sclerosis

  • D. Chari
  • Biology
    International Review of Neurobiology
  • 2007

Biology of oligodendrocyte and myelin in the mammalian central nervous system.

This review deals with the recent progress related to the origin and differentiation of the oligodendrocytes, their relationships to other neural cells, and functional neuroglial interactions under physiological conditions and in demyelinating diseases.

A functional role for EGFR signaling in myelination and remyelination

It is shown that 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) promoter–driven overexpression of human EGFR (hEGFR) accelerated remyelination and functional recovery following focal demyelinations of mouse corpus callosum and EGFR targeting holds promise for enhancing oligodendrocyte regeneration and myelin repair.

Expression of viral and myelin gene transcripts in a murine CNS demyelinating disease caused by a coronavirus

The histological features of the demyelinating disease were correlated with the spatial and temporal distribution of viral transcripts and the expression of oligodendrocyte‐specific genes in the spinal cord of diseased mice, and increased expression of myelin gene transcripts occurred in a synchronized manner and with a cellular distribution reminiscent of that seen in developmental myelination.
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