Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development.

@article{Sprkel2002OligodendrocytesEE,
  title={Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development.},
  author={Olaf Sp{\"o}rkel and Thomas Uschkureit and Heinrich B{\"u}ssow and W. Stoffel},
  journal={Glia},
  year={2002},
  volume={37 1},
  pages={19-30}
}
Oligodendroglia and Schwann cells synthesize myelin-specific proteins and lipids for the assembly of the highly organized myelin membrane of the motor-sensory axons in the central (CNS) and peripheral nervous system (PNS), respectively, allowing rapid saltatory conduction. The isoforms of the main myelin proteins, the peripheral myelin basic isoproteins (MBP) and the integral proteolipid proteins, PLP and DM20, arise from alternative splicing. Activation of a cryptic splice site in exon III of… CONTINUE READING

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