Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury.

Romain Marignier, Adeline Nicolle, +8 authors Pascale Giraudon
Published 2010 in Brain : a journal of neurology

Abstract

Devic's neuromyelitis optica is an inflammatory demyelinating disorder normally restricted to the optic nerves and spinal cord. Since the identification of a specific autoantibody directed against aquaporin 4, neuromyelitis optica-immunoglobulin G/aquaporin 4 antibody, neuromyelitis optica has been considered an entity distinct from multiple sclerosis… (More)

DOI: 10.1093/brain/awq177

Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies

Benedikt Grünewald, Jeffrey L. Bennett, Klaus V. Toyka, Claudia Sommer, Christian Geis
International journal of molecular sciences
2016

Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury.

Abstract

Topics

5 Figures and Tables

Cited By

Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies

Neuromyelitis optica study model based on chronic infusion of autoantibodies in rat cerebrospinal fluid

Neuromyelitis optica: a positive appraisal of seronegative cases.

NMO sera down-regulate AQP4 in human astrocyte and induce cytotoxicity independent of complement.

Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica

Bioenergetic Failure in Rat Oligodendrocyte Progenitor Cells Treated with Cerebrospinal Fluid Derived from Multiple Sclerosis Patients

Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica

Elevated cerebrospinal fluid uric acid during relapse of neuromyelitis optica spectrum disorders

Modeling neurological diseases using iPSC-derived neural cells

Neuromyelitis Optica: Deciphering a Complex Immune-Mediated Astrocytopathy.

References

Losing your nerves? Maybe it's the antibodies

Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2

The spectrum of neuromyelitis optica.

A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.

Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum.

Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study.

Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment.

Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis.

Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis.

Glutamine synthetase and glutamine synthetase-like protein from human brain: purification and comparative characterization.

Slides referencing similar topics

Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury.

Abstract

Topics

5 Figures and Tables

Cited By

Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies

Neuromyelitis optica study model based on chronic infusion of autoantibodies in rat cerebrospinal fluid

Neuromyelitis optica: a positive appraisal of seronegative cases.

NMO sera down-regulate AQP4 in human astrocyte and induce cytotoxicity independent of complement.

Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica

Bioenergetic Failure in Rat Oligodendrocyte Progenitor Cells Treated with Cerebrospinal Fluid Derived from Multiple Sclerosis Patients

Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica

Elevated cerebrospinal fluid uric acid during relapse of neuromyelitis optica spectrum disorders

Modeling neurological diseases using iPSC-derived neural cells

Neuromyelitis Optica: Deciphering a Complex Immune-Mediated Astrocytopathy.

References

Losing your nerves? Maybe it's the antibodies

Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2

The spectrum of neuromyelitis optica.

A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.

Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum.

Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study.

Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment.

Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis.

Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis.

Glutamine synthetase and glutamine synthetase-like protein from human brain: purification and comparative characterization.

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