Oligodendrocytes are a Novel Source of Amyloid Peptide Generation

@article{Skaper2009OligodendrocytesAA,
  title={Oligodendrocytes are a Novel Source of Amyloid Peptide Generation},
  author={Stephen D Skaper and Nicholas A. Evans and Peter Ernest Soden and Claudia Rosin and Laura Facci and J. Channing Richardson},
  journal={Neurochemical Research},
  year={2009},
  volume={34},
  pages={2243-2250}
}
Alzheimer’s disease is characterised by regional neuronal degeneration, synaptic loss, and the progressive deposition of the 4 kDa β-amyloid peptide (Aβ) in senile plaques and accumulation of tau protein as neurofibrillary tangles. Aβ derives from the larger precursor molecule, amyloid precursor protein (APP) by proteolytic processing via β- and γ-secretases. While APP expression is well documented in neurons and astrocytes, the case for oligodendrocytes is less clear. The latter cell type is… CONTINUE READING
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Identification of a novel aspartic protease (Asp2) as b-secretase

  • I Hussain, D Powell, DR Howlett
  • Mol Cell Neurosci
  • 1999
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