• DOI:10.3109/00207454.2015.1025778
Corpus ID: 21448714

Oligodendrocytes and Alzheimer's disease

@article{Cai2016OligodendrocytesAA,
  title={Oligodendrocytes and Alzheimer's disease},
  author={Zhiyou Cai and M. Xiao},
  journal={International Journal of Neuroscience},
  year={2016},
  volume={126},
  pages={104 - 97}
}

• Zhiyou Cai, M. Xiao
• Published 2016
• Medicine
• International Journal of Neuroscience

Extensive evidence has indicated that the breakdown of myelin is associated with Alzheimer's disease (AD) since the vulnerability of oligodendrocytes under Alzheimer's pathology easily induces the myelin breakdown and the loss of the myelin sheath which might be the initiating step in the changes of the earliest stage of AD prior to appearance of amyloid and tau pathology. Considerable research implicated that beta-amyloid (Aβ)-mediated oligodendrocyte dysfunction and myelin breakdown may be… Expand

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