Oligodendrocytes and Alzheimer's disease

@article{Cai2016OligodendrocytesAA,
  title={Oligodendrocytes and Alzheimer's disease},
  author={Zhiyou Cai and Ming Xiao},
  journal={International Journal of Neuroscience},
  year={2016},
  volume={126},
  pages={104 - 97}
}
  • Z. Cai, M. Xiao
  • Published 1 February 2016
  • Biology
  • International Journal of Neuroscience
Extensive evidence has indicated that the breakdown of myelin is associated with Alzheimer's disease (AD) since the vulnerability of oligodendrocytes under Alzheimer's pathology easily induces the myelin breakdown and the loss of the myelin sheath which might be the initiating step in the changes of the earliest stage of AD prior to appearance of amyloid and tau pathology. Considerable research implicated that beta-amyloid (Aβ)-mediated oligodendrocyte dysfunction and myelin breakdown may be… 
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76 Citations

Oligodendroglial Cells in Alzheimer's Disease.
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Therapies that target NG2-glia are likely to have positive effects on myelination and neuroprotection in AD, and the hypothesis that a vicious cycle of myelin loss and failure of regeneration from NG2 -glia plays a key role in AD is proposed.
Myelin injury in the central nervous system and Alzheimer’s disease
Role of Neuron and Glia in Alzheimer’s Disease and Associated Vascular Dysfunction
TLDR
Overall, the current review informs about the interaction of neuronal and glial cell types in AD pathogenesis and its critical association with cerebrovascular dysfunction.
Iron Pathophysiology in Alzheimer's Diseases.
TLDR
Future research will focus on iron as an opportunity to study the mechanism of the occurrence and development of AD from the iron steady state to more fully clarify the etiology and prevention strategies.
Unravelling the glial response in the pathogenesis of Alzheimer's disease
TLDR
A review of recent studies attempting to unravel the glial response during the course of disease and how this action may dictate the outcome of neurodegeneration examines the importance of regional heterogeneity of glial cells within the CNS during healthy aging and disease.
Molecular Bases of Alzheimer’s Disease and Neurodegeneration: The Role of Neuroglia
TLDR
The main physiological functions of the glial cells are described and the link between neuroglia and the most studied molecular bases of AD is discussed, with particular attention to their role in terms of neurodegeneration.
The neuroinflammatory interleukin-12 signaling pathway drives Alzheimer’s disease-like pathology by perturbing oligodendrocyte survival and neuronal homeostasis
TLDR
IL-12, but not IL-23 is the main driver of AD-specific IL-12/IL-23 neuroinflammation, which alters neuronal and oligodendrocyte functions, and may foster first clinical trials in AD subjects using this novel neuroimmune target.
Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner
  • I. Ferrer
  • Biology, Medicine
    Progress in Neurobiology
  • 2018
Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease
Blood-Based Biomarkers of Neuroinflammation in Alzheimer’s Disease: A Central Role for Periphery?
TLDR
Interestingly, as a result of the bidirectional communication between the brain and the periphery, the blood compartment ends up reflecting several pathological changes occurring in the AD brain and can represent an accessible source for such biomarkers.
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References

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