Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth

  title={Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth},
  author={Kevin C. Wang and Vuk Koprivica and Jieun A. Kim and Rajeev Sivasankaran and Yong Guo and Rachel L Neve and Zhigang He},
The inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in the adult mammalian central nervous system (CNS). In addition to myelin-associated glycoprotein (MAG) and Nogo-A, available evidence suggests the existence of additional inhibitors in CNS myelin. We show here that a glycosylphosphatidylinositol (GPI)-anchored CNS myelin protein, oligodendrocyte-myelin glycoprotein (OMgp), is a potent inhibitor of neurite outgrowth in cultured neurons. Like… 

Overcoming inhibitors in myelin to promote axonal regeneration

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beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones

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