Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth.

  title={Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth.},
  author={Vicky Kottis and Pierre Thibault and Daniel D. Mikol and Zhi-cheng Xiao and Rulin Zhang and Pauline Dergham and Peter E. Braun},
  journal={Journal of neurochemistry},
  volume={82 6},
A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by… CONTINUE READING
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