Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology.

  title={Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology.},
  author={Minh Vu Chuong Nguyen and Christy A Felice and Fang Du and Matthew V Covey and John K. Robinson and Gail Mandel and Nurit Ballas},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={33 48},
Mutations in the methyl-CpG binding protein 2 gene, Mecp2, affect primarily the brain and lead to a wide range of neuropsychiatric disorders, most commonly Rett syndrome (RTT). Although the neuropathology of RTT is well understood, the cellular and molecular mechanism(s), which lead to the disease initiation and progression, has yet to be elucidated. RTT was initially attributed only to neuronal dysfunction, but our recent studies and those of others show that RTT is not exclusively neuronal… CONTINUE READING
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Adult neural function requires MeCP 2

  • MV Nguyen, F Du, +4 authors N Ballas
  • Science
  • 2012
Highly Influential
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