Oligodendrocyte dysfunction in schizophrenia and bipolar disorder

@article{Tkachev2003OligodendrocyteDI,
  title={Oligodendrocyte dysfunction in schizophrenia and bipolar disorder},
  author={Dmitri Tkachev and Michael L. Mimmack and Margaret M. Ryan and Matthew Thomas Wayland and Tom Freeman and Peter B. Jones and Michael P. Starkey and Maree J. Webster and Robert H. Yolken and Sabine Bahn},
  journal={The Lancet},
  year={2003},
  volume={362},
  pages={798-805}
}
BACKGROUND Results of array studies have suggested abnormalities in expression of lipid and myelin-related genes in schizophrenia. Here, we investigated oligodendrocyte-specific and myelination-associated gene expression in schizophrenia and bipolar affective disorder. METHODS We used samples from the Stanley brain collection, consisting of 15 schizophrenia, 15 bipolar affective disorder, and 15 control brains. Indexing-based differential display PCR was done to screen for differences in gene… 
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The MAG knockout mouse, missing a myelin-related gene linked to schizophrenia, may prove to be a useful animal model for the dysmyelination observed in the human disease.
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