Oligodendrocyte development and thyroid hormone.

  title={Oligodendrocyte development and thyroid hormone.},
  author={Angeles Rodr{\'i}guez-Pe{\~n}a},
  journal={Journal of neurobiology},
  volume={40 4},
Thyroid hormone plays an important role in brain development and is essential to ensure a normal myelination. The effects of thyroid hormone are mediated by nuclear thyroid hormone receptors, which act as ligand-regulated transcription factors. There are several isoforms encoded by two genes, alpha and beta. Developmental studies have shown that alpha isoforms are widely expressed in the fetal brain, while beta isoforms expression is more restricted with a dramatic increase that begins at birth… CONTINUE READING


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