Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis

@article{Yuen2014OligodendrocyteEncodedHF,
  title={Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis},
  author={Tracy Yuen and John Christian Silbereis and Am{\'e}lie Griveau and Sandra M. Chang and Richard Daneman and Stephen P J Fancy and Hengameh Zahed and Emin Maltepe and David H Rowitch},
  journal={Cell},
  year={2014},
  volume={158},
  pages={383-396}
}
Myelin sheaths provide critical functional and trophic support for axons in white matter tracts of the brain. Oligodendrocyte precursor cells (OPCs) have extraordinary metabolic requirements during development as they differentiate to produce multiple myelin segments, implying that they must first secure adequate access to blood supply. However, mechanisms that coordinate myelination and angiogenesis are unclear. Here, we show that oxygen tension, mediated by OPC-encoded hypoxia-inducible… CONTINUE READING
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