Oligodendrocyte Differentiation and Myelination Is Potentiated via GABAB Receptor Activation

  title={Oligodendrocyte Differentiation and Myelination Is Potentiated via GABAB Receptor Activation},
  author={Mari Paz Serrano-Regal and Irene Luengas-Escuza and Laura Bay{\'o}n-Cordero and Naroa Ibarra-Aizpurua and Elena Alberdi and Alberto P{\'e}rez-Samart{\'i}n and Carlos Matute and Mar{\'i}a Victoria S{\'a}nchez-G{\'o}mez},

Expression and Function of GABA Receptors in Myelinating Cells

Evidence supporting the novel role of GABA with an emphasis on the molecular identity of the receptors expressed in glial cells and the possible signaling pathways involved in their actions is highlighted.

Postnatal myelination of the immature rat cingulum is regulated by GABAB receptor activity

In vivo study indicates GABAB receptor activity as a potential modulator of oligodendroglial development after pharmacological inhibition of GABAA and GABAB in the neonatal rat brain.

GABA Receptor Agonists Protect From Excitotoxic Damage Induced by AMPA in Oligodendrocytes

The results suggest that GABAR activation initiates alternative molecular mechanisms that attenuate AMPA-mediated apoptotic excitotoxicity in oligodendrocytes by interfering with expression of GluR subunits in membranes and with calcium-dependent intracellular signaling pathways.

Neuron to Oligodendrocyte Precursor Cell Synapses: Protagonists in Oligodendrocyte Development and Myelination, and Targets for Therapeutics

How the understanding of the synaptic connectivity between neurons and OPCs can inform future therapeutics in demyelinating disease is focused on, and gaps in the literature that would inform new therapies for remyelination are discussed.

GABAA Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain α3 and γ1 Subunits and Present Differential Functional and Pharmacological Properties

It is identified that the GABAAR subunit combination α3β2γ1 conforms the bulk of GABAARs in oligodendrocytes from rat neonates, and these receptors have differential pharmacological properties that allow specific positive modulation by β-carbolines.

Oligodendroglial GABAergic Signaling: More Than Inhibition!

This review elaborate on the physiological role of GABA receptors within the oligodendrocyte lineage and conclude with a description of these receptors as putative targets in treatments of CNS diseases.

GABABR agonist baclofen promotes central nervous system remyelination

It is demonstrated that Bac increases myelin protein production following lysolecithin (LPC)-induced demyelination in cerebellar ex vivo slices, and this suggests that Bac should be considered as a potential therapeutic agent, not only to treat spasticity, but also to improve remyelinating in patients with MS.

GABA A Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain a 3 and g 1 Subunits and Present Differential Functional and Pharmacological Properties s

It is found that GABA A R composed of a 3 b 2 g 1 subunits mimicked the characteristics of the endogenous receptor when expressed heterologously in Xenopus laevis oocytes, and the identification of b -carbolines as selective enhancers of GABA A Rs in OLs may help to study the role of GABAergic signaling during myelination.

Interactions Between Astrocytes and Oligodendroglia in Myelin Development and Related Brain Diseases.

This article focuses on recapitulating how the interactions between these two types of glial cells modulate myelination, and how the AST-OLG interactions are involved in protecting the integrity of the blood-brain barrier (BBB) and regulating synaptogenesis and neural activity.

Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain

The present review summarizes recent findings in the field to get further insights into physio-pathophysiological processes and possible therapeutic mechanisms of drug actions.



Developing oligodendrocytes express functional GABAB receptors that stimulate cell proliferation and migration

The presence of GABABRs in developing oligodendrocytes provides a new mechanism for neuronal–glial interactions during development and may offer a novel target for promoting remyelination following white matter injury.

A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination

It is shown that NMDAR plays a critical role in the regulation of OPCs differentiation in vitro and remyelination in cuprizone model which may provide potential target for the treatment of demyelinating disease.

Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode length

It is shown that endogenously released GABA, acting on GABAA receptors, greatly reduces the number of oligodendrocyte lineage cells, implying that, during development, GABA can act as a local environmental cue to control myelination and thus influence the conduction velocity of action potentials within the CNS.

Central Role of GABA in Neuron–Glia Interactions

The cellular mechanisms allowing the major types of glial cells to sense and transmit GABAergic signals are discussed and an overview of potential roles of this signaling pathway in developing and mature brains is given.

GABA-B receptors in the PNS have a role in Schwann cells differentiation?

It is argued that GABA-B receptors do not control exclusively the in vivo differentiation yielding the myelinating SC, but are also fundamental in regulating the SC plasticity versus the non-myelinating state.

Expression and Developmental Regulation of a GABAA Receptor in Cultured Murine Cells of the Oligodendrocyte Lineage

The density of GABAA receptors in the membrane, as calculated on the basis of whole cell currents and membrane capacitance, decreased by a factor of 100 when cells matured along the oligodendrocyte lineage, indicating a developmental regulation of the expression of the GABA receptor.

GABAergic regulation of cerebellar NG2-cell development is altered in perinatal white matter injury

The results indicate that GABAergic signaling regulates NG2 cell differentiation and proliferation in vivo, and suggest that its perturbation is a key factor in DWMI.

Neuronal activity and AMPA‐type glutamate receptor activation regulates the morphological development of oligodendrocyte precursor cells

An important role is explored for AMPAR but not NMDAR in mediating the activity‐dependent signals that regulate OPC morphology, development and myelination in cerebellar slice cultures.

GABAB receptor subunit expression in glia

Synaptic signaling between GABAergic interneurons and oligodendrocyte precursor cells in the hippocampus

It is found that quantal release of GABA from interneurons elicits GABAA receptor currents with rapid rise times in hippocampal OPCs, and that the GABA-induced Cl− flux generated by these events may influence oligodendrocyte development by regulating the efficacy of glutamatergic signaling in O PCs.