Oligoclonal immune response in cerebral cavernous malformations. Laboratory investigation.

@article{Shi2007OligoclonalIR,
  title={Oligoclonal immune response in cerebral cavernous malformations. Laboratory investigation.},
  author={Changbin Shi and Robert Shenkar and H. Hunt Batjer and Irene J. Check and I A Awad},
  journal={Journal of neurosurgery},
  year={2007},
  volume={107 5},
  pages={1023-6}
}
OBJECT Mechanisms of cerebral cavernous malformation (CCM) pathogenesis include genetic predisposition in some cases, but other factors are likely to be involved in lesion proliferation and clinical manifestations. Given the unique antigenic milieu of CCMs, there may be a characteristic immune response in these lesions. We hypothesize that the immunoglobulin (Ig) fraction in CCMs reflects an oligoclonal immune response not present in paired sera from the same patients or in other types of… CONTINUE READING

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