Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes.

@article{Balk1991OligoclonalEA,
  title={Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes.},
  author={Steven P. Balk and Ellen Catherine Ebert and Richard Blumenthal and Francis V. McDermott and Kai W Wucherpfennig and Steven B. Landau and Richard S Blumberg},
  journal={Science},
  year={1991},
  volume={253 5026},
  pages={
          1411-5
        }
}
A human intestinal intraepithelial lymphocyte (IEL) T cell line was established from jejunum to characterize the structure and function of the alpha beta T cell antigen receptors (TCRs) expressed by this population. Single-sided polymerase chain reaction (PCR) amplification cloning and quantitative PCR amplification of the TCR chains from the cell line and from fresh IELs demonstrated that IELs were oligoclonal. The IEL T cell line exhibited CD1-specific cytotoxicity and a dominant IEL T cell… CONTINUE READING
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