Oligoclonal bands in multiple sclerosis cerebrospinal fluid: An update on methodology and clinical usefulness

@article{Link2006OligoclonalBI,
  title={Oligoclonal bands in multiple sclerosis cerebrospinal fluid: An update on methodology and clinical usefulness},
  author={Hans Link and Yu-min Huang},
  journal={Journal of Neuroimmunology},
  year={2006},
  volume={180},
  pages={17-28}
}
Two or more oligoclonal IgG bands (OB) detected by separation of cerebrospinal fluid (CSF) proteins while not demonstrable in corresponding serum reflect a local B-cell response accompanying central nervous system (CNS) inflammation. Using optimized, standardized methodology, preferentially protein separation by isoelectric focusing followed by immunoblotting, more than 95% of patients with multiple sclerosis (MS) have CSF OB of IgG class not detectable in serum, thereby providing powerful… 
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The diagnostic significance of oligoclonal bands in CSF for MS/CIS can be improved by restricting interpretation to the delta banding pattern alone, which was observed over a 2-year period.
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Despite the lower frequency of positive IgG-OCB patterns in patients, both subgroups were mostly similar with regard to their clinical and demographic characteristics suggesting that the OCB status lacks prognostic significance in MS.
revalence of cerebrospinal fluid oligoclonal IgG bands in Greek atients with clinically isolated syndrome and multiple sclerosis
Lower prevalence of cerebrospinal fluid oligoclonal IgG bands (IgG-OCBs) has been reported in multiple sclerosis (MS) patients from Southern Europe compared to other western countries. Objectives: We…
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Although the measurement of CSF KFLC is a rapid and quantitative easy to standardize tool, it is almost equal but not superior to OCB with regard to diagnostic sensitivity and specificity in patients with early MS.
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Results indicate that CSF analysis can help differentiate between MS and ADEM and that, similarly to EAE, the 'mirror pattern' observed in ADEM accounts for a predominantly systemic immune activation.
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TLDR
An elevated immunoglobulin G index adds diagnostic value versus oligoclonal bands and saves time in the diagnostic process.
Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis: associations with disease course and progression
TLDR
OCB positivity and elevated total CSF IgG and protein were moderately associated with a PPMS disease course, but not disease progression, suggesting a testing bias.
Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo.
TLDR
The results suggest that the frequency of CSF OCB is much lower in Brazilian MS patients from São Paulo city than that reported in MS series from Caucasian populations.
Intrathecal oligoclonal IgG bands are infrequently found in neuro-Behçet's disease.
TLDR
The rare presence of oligoclonal IgG bands in CSF can be utilized as another laboratory finding in the diagnosis of NBD.
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TLDR
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