Oligoclonal bands in multiple sclerosis cerebrospinal fluid: An update on methodology and clinical usefulness

@article{Link2006OligoclonalBI,
  title={Oligoclonal bands in multiple sclerosis cerebrospinal fluid: An update on methodology and clinical usefulness},
  author={Hans Link and Yu-min Huang},
  journal={Journal of Neuroimmunology},
  year={2006},
  volume={180},
  pages={17-28}
}
Two or more oligoclonal IgG bands (OB) detected by separation of cerebrospinal fluid (CSF) proteins while not demonstrable in corresponding serum reflect a local B-cell response accompanying central nervous system (CNS) inflammation. Using optimized, standardized methodology, preferentially protein separation by isoelectric focusing followed by immunoblotting, more than 95% of patients with multiple sclerosis (MS) have CSF OB of IgG class not detectable in serum, thereby providing powerful… 
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