Oligoclonal T-cells in blood and target tissues of patients with anti-Hu syndrome.

  title={Oligoclonal T-cells in blood and target tissues of patients with anti-Hu syndrome.},
  author={Anne Plonquet and Romain Kroum Gherardi and Alain Cr{\'e}ange and Jean Claude Antoine and Baya Benyahia and W Grisold and Markus Drlicek and P. Dreyfus and J{\'e}r{\^o}me Honnorat and Chah{\'e}ra Khouatra and H{\'e}l{\`e}ne Rouard and F. J. Authier and Jean Pierre Farcet and J. Y. Delattre and Marie H{\'e}l{\`e}ne Delfau-Larue},
  journal={Journal of neuroimmunology},
  volume={122 1-2},
T-cell clones of unknown significance (TCUS), assessed by monoclonal or oligoclonal T-cell patterns in PCR-DGGE, were detected in blood of 7/9 patients with anti-Hu syndrome. Clonal patterns were also detected in 2/2 neoplastic lymph nodes, and in 2/2 inflamed dorsal root ganglia from three patients. Only some T-cell clones found in target tissues were also detected in blood or non-target tissues, and likely corresponded to TCUS. In one patient, an identical T-cell clone was found in both… CONTINUE READING
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