Oligoclonal IgG band patterns in inflammatory demyelinating human and mouse diseases

@article{Franciotta2008OligoclonalIB,
  title={Oligoclonal IgG band patterns in inflammatory demyelinating human and mouse diseases},
  author={Diego Franciotta and Sandra Columba-Cabezas and Laura Andreoni and Sabrina Ravaglia and Enrico Marchioni},
  journal={Journal of Neuroimmunology},
  year={2008},
  volume={200},
  pages={125-128}
}
  • Diego Franciotta, Sandra Columba-Cabezas, +2 authors Enrico Marchioni
  • Published in Journal of Neuroimmunology 2008
  • Medicine
  • We evaluated oligoclonal IgG band (OCB) patterns obtained by analyzing paired cerebrospinal fluid (CSF) and serum samples of 77 patients with acute demyelinating encephalomyelitis (ADEM) and 411 patients with multiple sclerosis (MS). OCBs were searched with isoelectric focusing and capillary immunoblotting. CSF-restricted OCBs were found in 89% of MS patients and 10% of ADEM patients (p<0.0001). Identical serum and CSF OCBs ('mirror pattern'), or no OCBs, were detected in 10% of MS patients and… CONTINUE READING

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