Oligo- and poly-nucleotides: 50 years of chemical synthesis.

Abstract

It is fifty years since the first chemical synthesis of a dinucleoside phosphate and a dinucleotide with natural 3'-->5'-internucleotide linkages was reported. The main developments in the methodology of oligo- and poly-nucleotide synthesis that have taken place since are described. 

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Cite this paper

@article{Reese2005OligoAP, title={Oligo- and poly-nucleotides: 50 years of chemical synthesis.}, author={Colin B. Reese}, journal={Organic & biomolecular chemistry}, year={2005}, volume={3 21}, pages={3851-68} }