Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation

@article{Yu2013Olig2TC,
  title={Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation},
  author={Yang Yu and Ying Chen and Bongwoo Kim and Haibo Wang and Chuntao Zhao and Xuelian He and Lei Liu and Wei Liu and Lai Man Natalie Wu and M. Castro Mao and Jonah R Chan and Jiang Wu and Qing Richard Lu},
  journal={Cell},
  year={2013},
  volume={152},
  pages={248-261}
}
Establishment of oligodendrocyte identity is crucial for subsequent events of myelination in the CNS. Here, we demonstrate that activation of ATP-dependent SWI/SNF chromatin-remodeling enzyme Smarca4/Brg1 at the differentiation onset is necessary and sufficient to initiate and promote oligodendrocyte lineage progression and maturation. Genome-wide multistage studies by ChIP-seq reveal that oligodendrocyte-lineage determination factor Olig2 functions as a prepatterning factor to direct Smarca4… CONTINUE READING
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